I'm a big fan of grid designs. structure. Conformity. And then breaking that conformity. Designing your site around a grid always makes things seem to flow a bit better as well as hold up against any future changes and revisions. Or "reboots", if that's your thing.
There are a few great articles about grid designs that I highly recommend reading. But if you're looking for a quick and simple way to figure out that grid, a site was forwarded to me this morning that you may find interesting.